This article examines strategies to reduce participant and provider burden in clinical trials while ensuring high-quality data collection. It highlights simplifying questionnaires, leveraging technology like electronic PROs (ePROs), and offering flexible survey options to enhance participant engagement. For providers, integrating PROs into workflows, delegating tasks, and offering training reduces administrative strain. Ethical and equitable practices, such as culturally sensitive designs, are emphasized to ensure inclusivity. Drawing on evidence-based recommendations, including insights from Aiyegbusi et al. (2024), the article showcases platforms like Castor ePRO as effective solutions to streamline PRO collection and improve clinical trial outcomes.